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KMID : 0363620060270030178
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 3 p.178 ~ p.186
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The Effects of Radix Scrophulariae (玄蔘) on the Hyperthyroidism of Rats
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Park Chan-Uk
Cho Chung-Sik
Kim Chul-Jung
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Abstract
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Objective: The aim was to study experimentally the effects of Radix Scrophulariae (玄蔘) induced by Sodium levothyroxine.
Methods: Sprague-Dawley rats Were separated into four groups. Except for the normal group, the other three were treated with sodium levothyroxine 160{mu}g/kg$ for 5 days. Among the three groups, two (except the control) were treated with Radix Scrophulariae extract 0.5g/kg (HNS 1) or 1.0g/kg (HNS II). T_3-uptake,;T_3,;T_4, TSH, total cholesterol, glucose, ALP, AST, ALT, free fatty acid, beta-lipoprotein, and change in the serum of rats were measured after medication of solid extract of Radix Scrophulariae.
Results: As a result of this study, HNS II showed significant decrease in comparison with the control in the serum T_3-uptake,;T_3 ALP and free fatty acid content. HNS I and HNS II showed significant decrease in comparison with the control in the serum of T_4 and glucose content. HNS I and HNS II showed significant increase in comparison with the control in the serum of TSH and total cholesterol content. In body weight, HNS I and HNS II showed significant increase in comparison with the control.
Conclusion: These results suggest that Radix Scrophulariae is effective to cure hyperthyroidism.
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KEYWORD
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Hyperthyroidism, Radix Scrophulariae (玄蔘), sodium levothyroxine
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